More than one fourth of humans are estimated to be chronically infected with Toxoplasma gondii. In patients with intact immune systems, T. gondii infection may be asymptomatic or may cause an influenza-like illness, lymphadenopathy, or eye disease. In fact, T. gondii is a leading cause of posterior uveitis and a major cause of childhood blindness. In persons with AIDS or other immune deficiencies, initial infection or reactivation of previous infection can cause severe brain, lung or eye disease. Developing fetuses can acquire infection during pregnancy, resulting in miscarriage or severe birth defects. Toxoplasmosis is also an important veterinary disease.  Current treatments are limited by allergic reactions and hematologic toxicity.

Our research has identified and developed promising preclinical candidates for toxoplasmosis and we are currently exploring new drug targets for toxoplasmosis.